Journal
AMERICAN JOURNAL OF TRANSPLANTATION
Volume 10, Issue 1, Pages 40-46Publisher
WILEY
DOI: 10.1111/j.1600-6143.2009.02859.x
Keywords
Apoptosis; B7-H1; orthotopic liver transplantation; regulatory cell; spontaneous tolerance
Categories
Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan [14370367, 13671250, 17390355]
- NIH [DK 058316]
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK058316, R01DK084192] Funding Source: NIH RePORTER
Ask authors/readers for more resources
The programmed death-1 (PD-1)/B7-H1 pathway acts as an important negative regulator of immune responses. We herein investigated the role of the PD-1/B7-H1 pathway in establishing an immunological spontaneous tolerance status in mouse liver allografting. B7-H1 is highly expressed on the donor-derived tissue cells and it is also associated with the apoptosis of infiltrating T cells in the allografts. Strikingly, a blockade of the PD-1/B7-H1 pathway via anti-B7-H1mAb or using B7-H1 knockout mice as a donor led to severe cell infiltration as well as hemorrhaging and necrosis, thus resulting in mortality within 12 days. Furthermore, the expression of the FasL, perforin, granzyme B, iNOS and OPN mRNA in the liver allografts increased in the antibody-treated group in comparison to the controls. Taken together, these data revealed that the B7-H1 upregulation on the tissue cells of liver allografts thus plays an important role in the apoptosis of infiltrating cells, which might play a critical role of the induction of the spontaneous tolerance after hepatic transplantation in mice.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available