Journal
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
Volume 1768, Issue 12, Pages 3098-3106Publisher
ELSEVIER
DOI: 10.1016/j.bbamem.2007.09.006
Keywords
micelle; bicelle; structure; Smr; multidrug resistance
Categories
Funding
- NIGMS NIH HHS [P41 GM066354, GM66354, GM72085, R01 GM072085-03, R01 GM072085] Funding Source: Medline
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Considerable progress has been made recently on solution NMR studies of multi-transmembrane helix membrane protein systems of increasing size. Careful correlation of structure with function has validated the physiological relevance of these studies in detergent micelles. However, larger micelle and bicelle systems are sometimes required to stabilize the active forms of dynamic membrane proteins, such as the bacterial small multidrug resistance transporters. Even in these systems with aggregate molecular weights well over 100 kDa, solution NMR structural studies are feasible-but challenging. (C) 2007 Elsevier B.V. All rights reserved.
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