Journal
JOURNAL OF VIROLOGY
Volume 81, Issue 24, Pages 13938-13942Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01745-07
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Funding
- NHLBI NIH HHS [T32 HL007775] Funding Source: Medline
- NIAID NIH HHS [R21 AI064031, U19 AI066290, R21AI64031-A1, R01 AI058862, U19 AI066290-01, R01AI058862] Funding Source: Medline
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Resting CD4(+) T cells restrict human immunodeficiency virus (HIV) infection at a step prior to integration. Despite this restriction, we showed previously that HIV integration occurs in resting CD4(+) T cells in vitro, albeit at lower levels than in activated CD4(+) T cells. Here we show that addition of deoxynucleosides enhanced integration and 2LTR formation in resting CD4(+) T cells but that the kinetics were still significantly delayed compared to those of activated T cells. Thus, deoxynucleoside addition partially overcomes the restriction to HIV infection in resting CD4(+) T cells.
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