Journal
AMERICAN JOURNAL OF TRANSPLANTATION
Volume 9, Issue 10, Pages 2372-2382Publisher
WILEY-BLACKWELL PUBLISHING, INC
DOI: 10.1111/j.1600-6143.2009.02791.x
Keywords
IL6; magnetic resonance imaging (MRI); MCP-1; pancreatic islet transplantation; proinflammatory cytokines; superparamagnetic iron oxide contrast agents
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Funding
- Ezio Bonifacio (CRTD, Dresden, Germany)
- Fondazione Cariplo (EB/MLM) [JDRF JT01Y01, JDRF 31-2008-416]
- Fondazione Telethon Funding Source: Custom
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Islet transplantation is an effective therapy for restoring normoglycemia in type-1 diabetes, but long-term islet graft function is achieved only in a minority of cases. Noninvasive magnetic resonance imaging of pancreatic islets is an attractive option for real-time monitoring of graft evolution. So far, previous studies have been performed in the absence of a standardized labeling procedure and, besides a feasibility study in patients, the effectiveness and safety of various labeling approaches were tested only with high field magnets (4.7 T). In this study, we addressed: (a) standardization of a labeling procedure for human islets with clinically-approved contrast agent Endorem
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