Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 19, Issue 6, Pages 612-617Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2007.09.014
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Funding
- NIDDK NIH HHS [R01 DK062876-05, R01 DK051563-12, R01 DK062876, R01 DK051563] Funding Source: Medline
- NIGMS NIH HHS [T32 GM007315] Funding Source: Medline
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Adipocyte differentiation consists of a complex series of events in which scores of cellular and extracellular factors interact to transform a fibroblast-like preadipocyte into a mature, lipid-filled adipocyte. Many of the pathways influencing this process have been identified using well-characterized preadipocyte culture systems and have subsequently been confirmed in animal models. Research conducted over the past decade has established the Wnt/beta-catenin signaling pathway as an important regulator of adipocyte differentiation. While initial reports implicated activators of Wnt/beta-catenin signaling as potent inhibitors of adipogenesis, recent investigations of mesenchymal cell fate, obesity, and type 2 diabetes highlight significant additional roles for Wnt signaling in metabolism and adipocyte biology.
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