Optimizing measurement of self-reported adherence with the ACTG adherence questionnaire - A cross-protocol analysis

Background/Objective: The AIDS Clinical Trials Group (ACTG) Adherence Questionnaire is used extensively, but investigators frequently only use the first item of the questionnaire (4-day recall). Design/Methods: A secondary analysis was conducted to (1) estimate the validity and reliability of each of the 5 scale iterns and (2) compare the approach commonly used to summarize adherence data collected with the instrument (average 4-day recall) with alternate approaches derived using principal component (PC) analysis and the full questionnaire. We hypothesized that an estimate of adherence taking all items of the questionnaire into account would provide a stronger measure of adherence. Results: Logistic regression analyses showed that the first PC identified (PCl) was significantly correlated with plasma HIV RNA outcome (P < 0.0001 for ACTG 370 data and P = 0.006 for ACTG 398 data) and correlated with plasma HIV RNA better than average 4-day recall. An adherence index formulated using weights of PCl showed substantially greater variability in the range of adherence scores in comparison to average 4-day adherence recall alone. PCl compared favorably with 2 indices derived from medication event monitoring system data as well. Conclusions: Findings indicate that a superior assessment of antiretroviral adherence may be obtained with the ACTG Adherence Questionnaire by using the method employed in this analysis.