4.2 Article

Identification of hepatitis C virus subtype 2c by sequencing analysis in patients from Cordoba, Argentina

Journal

MEMORIAS DO INSTITUTO OSWALDO CRUZ
Volume 102, Issue 8, Pages 995-998

Publisher

FUNDACO OSWALDO CRUZ
DOI: 10.1590/S0074-02762007000800016

Keywords

hepatitis C virus; Argentina; HCV subtype 2c

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In Argentina, most information on hepatitis C virus (HCV) genotype distribution comes from studies carried out in Buenos Aires (east province). In order to identify HCV subtypes in central Argentina, nucleotide sequencing of core region was performed in samples from 36 patients living in Cordoba, the second most populated province of Argentina. The sequence analysis identified subtype 2c as the most prevalent (50%), followed by subtype 1b (33%) and to a lesser extent by subtypes 1a (11%), 3a (3%) and 4a (3%). This is the first report of circulation of HCV subtype 2c in this region of Argentina and also such high prevalence has never been found before in the genotype distribution of South America.

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