Journal
CURRENT OPINION IN PHARMACOLOGY
Volume 7, Issue 6, Pages 557-562Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.coph.2007.10.002
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Funding
- NIDDK NIH HHS [DK 55003, R01 DK055003-10A1, R01 DK056930, DK 54155, DK 41301, R01 DK055003, DK 56930, R01 DK054155, R01 DK054155-09A1, P30 DK041301-20, P30 DK041301, R01 DK056930-08] Funding Source: Medline
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Molecular sensing by gastrointestinal (GI) cells plays a crucial role in the control of multiple fundamental functions including digestion, regulation of caloric intake, pancreatic insulin secretion, and metabolism, as well as protection from ingested harmful drugs and toxins. These processes are likely to be mediated by the initiation of humoral and/or neural pathways through the activation of endocrine cells. However, the initial recognition events and mechanism(s) involved are still largely unknown. This article reviews the current evidence that the chemosensory machinery discovered in specialized neuroepithelial taste receptor cells of the lingual epithelium is operational in enteroendocrine open GI cells that sense the chemical composition of the luminal contents of the gut.
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