Journal
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
Volume 76, Issue 1-2, Pages 40-44Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jri.2007.03.009
Keywords
systemic inflammatory response; pre-eclampsia
Categories
Ask authors/readers for more resources
The immunological interaction between the mother and fetus has classically been thought of as one between paternal antigen and maternal T cells. However, the MHC antigen expression on human trophoblast and the immune cell populations present in the decidua suggest that this interaction primarily involves decidual NK cells rather than T cells, and this is supported by new functional studies. It is becoming apparent also that the maternal systemic immune response in pregnancy (Th1/Th2 shift) primarily involves NK cells. Aberrant NK cell activation both locally in the decidua and systemically in the maternal blood may be the cause of pre-eclampsia. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available