Journal
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
Volume 5, Issue 12, Pages 2323-2329Publisher
WILEY
DOI: 10.1111/j.1538-7836.2007.02770.x
Keywords
-
Categories
Funding
- NCI NIH HHS [CA 83134] Funding Source: Medline
- NHLBI NIH HHS [HL 086038, R01 HL089796, HL 052779, P01 HL057346, R01 HL052779, P50 HL 081011, HL 055709, HL 076810] Funding Source: Medline
Ask authors/readers for more resources
The plasma kallikrein-kinin system consists of the proteins factor XII (FXII), prekallikrein (PK), and high molecular weight kininogen. It was first recognized as a surface-activated coagulation system that is activated when blood or plasma interacts with artificial surfaces. Although surface-activated contact activation occurs in vivo in the case of tissue destruction or a developing thrombus, the physiologic basis for the activation and function of this system has not been delineated. New investigations indicate that there is a proteolytic pathway on cells for PK activation independent of FXII. This pathway for PK with subsequent FXII activation indicates physiologic activities. These activities include blood pressure regulation and modulation of thrombosis risk independently of hemostasis. Furthermore, they include regulation of endothelial cell proliferation, angiogenesis and apoptosis through a cellular-based, outside-in signaling system. The present characterizations of this system, which incorrectly had been thought to initiate coagulation, represent an evolution of understanding in this field.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available