Journal
PIGMENT CELL RESEARCH
Volume 20, Issue 6, Pages 498-506Publisher
BLACKWELL PUBLISHING
DOI: 10.1111/j.1600-0749.2007.00414.x
Keywords
ATF2; transcription; DNA damage; stress response; hypoxia; skin cancer; melanoma
Categories
Funding
- NCI NIH HHS [R01 CA059908-09, R01 CA099961, R01 CA051995, CA051995, R01 CA099961-03, R01 CA051995-13, CA099961, R01 CA059908] Funding Source: Medline
Ask authors/readers for more resources
Signal transduction pathways play a key role in the regulation of key cellular processes, including survival and death. Growing evidence points to changes in signaling pathway that occur during skin tumor development and progression. Such changes impact the activity of downstream substrates, including transcription factors. The activating transcription factor 2 (ATF2) has been implicated in malignant and non-malignant skin tumor developments. ATF2 mediates both transcription and DNA damage control, through its phosphorylation by JNK/p38 or ATM/ATR respectively. Here, we summarize our present understanding of ATF2 regulation, function and contribution to malignant and non-malignant skin tumor development.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available