Journal
JOURNAL OF CLINICAL NEUROSCIENCE
Volume 14, Issue 12, Pages 1178-1181Publisher
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.jocn.2007.01.009
Keywords
Parkinson's disease; dopamine agonists; gambling
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Three hundred patients with Parkinson's disease taking dopamine agonists were surveyed for the presence of compulsions. Fifty-eight reported active compulsions which had developed after initiation of dopamine agonists. These included 25 with sexual compulsions and 28 with self-described compulsive gambling, of whom 17 met criteria for pathologic, gambling. Males were over-represented. Patients with any compulsion and those with pathologic gambling were about 6 years younger than those without compulsions. These behavioral problems were not associated with an individual dopamine agonist, nor dose or duration, nor concomitant levodopa. Follow-up of the pathologic gamblers I year after intervention, which was cessation of the dopamine agonist in most cases, found ongoing but controlled gambling in five and complete cessation within 4 months in the remainder. (c) 2007 Elsevier Ltd. All rights reserved.
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