Journal
AMERICAN JOURNAL OF THERAPEUTICS
Volume 17, Issue 2, Pages 197-200Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MJT.0b013e3181a6ee1c
Keywords
anabolic therapy; antiresorptive therapy; RANK ligand; osteoporosis
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The existing drugs for treatment of osteoporosis are limited in scope, tolerability, and efficacy. Newer osteoclast-targeted agents like inhibitors of receptor activator nuclear factor kappa B pathway, Cathepsin K, and integrins are under clinical development. Osteoblast-targeted therapies include the agents acting through the Wnt signaling pathway like sclerostin antagonists. The potential molecular targets and the emerging drugs for treatment of osteoporosis are discussed in this review.
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