Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 11, Issue 6, Pages 636-643Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.cbpa.2007.09.010
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Funding
- NIGMS NIH HHS [R01 GM054839-12S1, GM022778, GM054839, P01 GM022778-310003, P01 GM022778, R01 GM054839] Funding Source: Medline
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The catalytic mechanisms employed by RNA are chemically more diverse than initially suspected. Divalent metal ions, nucleobases, ribosyl hydroxyl groups, and even functional groups on metabolic cofactors all contribute to the various strategies employed by RNA enzymes. This catalytic breadth raises intriguing evolutionary questions about how RNA lost its biological role in some cases, but not in others, and what catalytic roles RNA might still be playing in biology.
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