Journal
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 144, Issue 6, Pages 813-816Publisher
SPRINGER
DOI: 10.1007/s10517-007-0438-7
Keywords
type 2 diabetes mellitus; db/db mice; experimental model
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The genetic model of diabetes mellitus was studied on mutant C57Bl/KsLepr(db/+) mice. These mice were characterized by high concentrations of glucose and glycosylated hemoglobin in the blood, polyuria, polyphagia, polydipsia, progressive obesity, biphasic morphological changes in insular islets of the pancreas (hyperplasia and atrophy), fatty degeneration of the liver, and hypoplasia of the spleen tissue and lymph nodes. Our results indicate that C57Bl/KsLepr(db/+) mice serve as an adequate model of type 2 diabetes mellitus. This model is suitable for testing of therapeutic methods for type 2 diabetes mellitus.
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