Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 58, Issue 6, Pages 1207-1215Publisher
WILEY
DOI: 10.1002/mrm.21398
Keywords
amide proton transfer (APT); chemical exchange; chemical exchange saturation transfer (CEST); field inhomogeneity; magnetization transfer (MT)
Funding
- NCRR NIH HHS [P41RR14075] Funding Source: Medline
- NIA NIH HHS [K25 AG029415, K25 AG029415-05, K25 AG029415-02, K25 AG029415-04, K25 AG029415-01A1, K25 AG029415-03] Funding Source: Medline
- NINDS NIH HHS [5R01NS038477-08] Funding Source: Medline
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Chemical exchange saturation transfer (CEST) imaging provides an indirect detection mechanism that allows quantification of certain labile groups unobservable using conventional MRI. Recently, amide proton transfer (APT) imaging, a variant form of CEST imaging, has been shown capable of detecting lactic acidosis during acute ischemia, providing information complementary to that of perfusion and diffusion MRI. However, CEST contrast is usually small, and therefore, it is important to optimize experimental conditions for reliable and quantitative CEST imaging. In particular, CEST imaging is sensitive to So and Ell field, while on the other hand; field inhomogeneities persist despite recent advances in magnet technologies, especially for in vivo imaging at high fields. Consequently, correction algorithms that can compensate for field inhomogeneity-induced measurement errors in CEST imaging might be very useful. In this study, the dependence of CEST contrast on field distribution was solved and a correction algorithm was developed to compensate for field inhomogeneity-induced CEST imaging artifacts. In addition, the proposed algorithm was verified with both numerical simulation and experimental measurements, and showed nearly complete correction of CEST imaging measurement errors caused by moderate field inhomogeneity.
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