Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2007, Issue 35, Pages 5797-5815Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.200700409
Keywords
organocatalysis; enantioselective synthesis; asymmetric catalysis; Mannich reaction; imines
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The direct, asymmetric Mannich reaction catalyzed by small organic molecules offers a facile route to optically active alpha-or beta-amino acid derivatives and 1,2- and gamma-amino alcohols. One-pot reactions of unmodified carbonyl donors with preformed or in situ generated imines can be stereochemically controlled with Organic catalysts such as proline, chiral pyrrolidines, chiral Bronsted acids, and Cinchona alkaloids. The generated Mannich adducts can be further functionalized towards a variety of bioactive molecules. In this Microreview, recent contributions are discussed to present the methodology and synthetic advantages achieved so far in the asymmetric Mannich reaction. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
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