Journal
NATURE GENETICS
Volume 39, Issue 12, Pages 1431-1433Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.2007.32
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Funding
- Medical Research Council [G0000934] Funding Source: researchfish
- MRC [G0000934] Funding Source: UKRI
- Arthritis Research UK [17552] Funding Source: Medline
- Medical Research Council [G0000934(68341), G0000934] Funding Source: Medline
- Wellcome Trust [090532, 068545/Z/02, 068545, 076113] Funding Source: Medline
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The Wellcome Trust Case Control Consortium (WTCCC) identified nine single SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-5)-5 x 10(-7) in a genome-wide association screen. One, rs6920220, was unequivocally replicated ( trend P = 1.1 x 10(-8)) in a validation study, as described here. This SNP maps to 6q23, between the genes oligodendrocyte lineage transcription factor 3 (OLIG3) and tumor necrosis factor-alpha-induced protein 3 ( TNFAIP3).
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