Journal
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
Volume 30, Issue 6, Pages 537-540Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijantimicag.2007.07.007
Keywords
Acinetobacter; OXA-58 carbapenemase; time-kill assay; colistin; rifampicin
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This study evaluated the activity of colistin, rifampicin, imipenem and sulbactam/ampicillin alone or in combination against nine epidemic multidrug-resistant Acinetobacter baumannii isolates producing OXA-58 carbapenemase in Naples, Italy. The isolates were susceptible to colistin but differed in their resistance to imipenem and rifampicin. Time-kill studies showed a bactericidal effect for colistin but not for imipenem, rifampicin or sulbactam/ampicillin used as single agents. Synergism was observed with combinations of rifampicin + imipenem or sulbactam/ampicillin for all isolates and with colistin + rifampicin for isolates showing higher minimum inhibitory concentrations for rifampicin. Combined use of the antimicrobials tested may provide good therapeutic options for OXA-58 carbapenemase-producing A. baumannii infections. (C) 2007 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
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