Journal
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
Volume 344, Issue 6, Pages 447-451Publisher
ELSEVIER SCIENCE INC
DOI: 10.1097/MAJ.0b013e31824a0164
Keywords
Hypertension; Glucose and fat loading; Endothelium-dependent flow-mediated vasodilation
Categories
Ask authors/readers for more resources
Introduction: This study investigated the effects of combined glucose and fat load on glucose and lipid metabolism, as well as on vascular endothelial function, in hypertensive patients. Methods and Results: A total of 98 hypertensive patients were randomly divided into 3 groups that received an oral fat tolerance test (OFTT), an oral glucose tolerance test (OGTT) or a combined oral glucose and fat tolerance test (OGFTT). Endothelium-dependent flow-mediated brachial artery dilation (FMD) was measured by vascular ultrasound and was used as an indicator of vascular endothelial function. There were no significant differences in demographics or clinical characteristics among the 3 groups before the study. Immediately after the OGFTT, the serum triglyceride levels and the area under the curve for serum glucose in the OGFTT group were not significantly different from those in the other 2 groups. However, the 1-hour FMD in the OGFTT group was significantly reduced compared with that of the OGTT group (5.45 +/- 0.75 versus 9.46 +/- 1.32, P < 0.05), and the 4-hour FMD in the OGFTT group was also significantly reduced compared with the OFTT group (8.56 +/- 1.09 versus 9.76 +/- 2.00, P < 0.05). Conclusion: A combined glucose and fat load has a cumulative effect on vascular endothelial dysfunction in hypertensive patients.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available