Journal
NATURE REVIEWS GENETICS
Volume 8, Issue 12, Pages 921-931Publisher
NATURE RESEARCH
DOI: 10.1038/nrg2267
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Funding
- NIDDK NIH HHS [DK055736] Funding Source: Medline
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A network of interactions is called modular if it is subdivided into relatively autonomous, internally highly connected components. Modularity has emerged as a rallying point for research in developmental and evolutionary biology (and specifically evo-devo), as well as in molecular systems biology. Here we review the evidence for modularity and models about its origin. Although there is an emerging agreement that organisms have a modular organization, the main open problem is the question of whether modules arise through the action of natural selection or because of biased mutational mechanisms.
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