Journal
EMBO REPORTS
Volume 8, Issue 12, Pages 1129-1134Publisher
WILEY
DOI: 10.1038/sj.embor.7401115
Keywords
30 nm fibre; chromatin structure; DNA topology; linker histone
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Funding
- Medical Research Council [MC_U105184288] Funding Source: Medline
- Medical Research Council [MC_U105184288] Funding Source: researchfish
- MRC [MC_U105184288] Funding Source: UKRI
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The structure of the 30-nm chromatin fibre is an important determinant of the regulation of eukaryotic transcription. A fundamental issue is whether the stacking of nucleosomes in this fibre is organized as a one-start or two-start helix. We argue that all recent experimental data are compatible with a two-start helix and propose that the topology of the fibre, but not the mode of stacking the nucleosomes, is dependent on the length of the linker DNA. This arrangement conserves nucleosome stacking and thus the external morphology of the fibre, and also ensures that the fibre adopts the highest available packing density.
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