Journal
PARASITOLOGY INTERNATIONAL
Volume 56, Issue 4, Pages 313-316Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.parint.2007.06.003
Keywords
Echinococcus granulosus; genotypes 1 and 6; antigen B; 8-kDa-subunit; EgG1AgB8/5; EgG6AgB8/5; molecular characterization
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Funding
- FIC NIH HHS [1R01TW01565-05] Funding Source: Medline
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Antigen B in hydatid cyst fluid of Echinococcus granulosus is a polymeric lipoprotein of 160 kDa, and is an aggregate of several different but homologous small proteins with approximately 8 kDa which are encoded by a multigene family. Four genes encoding 8-kDa-subunit monomers of the antigen B have been identified from E. granulosus. Recently, we have isolated another novel gene from Echinococcus multilocularis encoding a fifth 8-kDa-subunit of AgB (named EmAgB8/5), predominantly transcribed in the adult worm, but not in vesicles of metacestodes. In this study, we cloned and characterized two ErnAgB8/5 homologue genes from E. granulosus genotypes 1 and 6 by PCR, and named as EgG1AgB8/5 and EgG6AgB8/5, respectively. The phylogenetic relationship of these genes with other genes encoding the antigen B 8-kDa-subunit monomers was also discussed. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
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