Journal
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
Volume 338, Issue 1, Pages 79-82Publisher
ELSEVIER SCIENCE INC
DOI: 10.1097/MAJ.0b013e3181a3dac8
Keywords
Fungal meningitis; Coccidioidomycosis; Antifungal therapy; Intrathecal therapy; Amphotericin B
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Coccidioidal meningitis is a lethal disease, and Current therapy is not curative or is burdened with serious toxicities and logistic difficulties. In a patient with refractory disease, continuous infusion amphotericin B therapy was given via a programmable implanted pump into the cisternal subarachnoid space. The patient progressively responded, evidenced clinically and by laboratory studies. Drug delivery issues were addressed during this course that could guide future use Of this modality, which is a promising novel avenue of therapy for chronic meningitis.
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