Three component, regioselective, one-pot synthesis of β-hydroxytriazoles from epoxides via 'click reactions'

2-Azidoalcohols derived in situ from epoxides and sodium azide undergo smooth coupling with alkynes under neutral conditions by means of 'click reactions' to furnish beta-hydroxytriazoles in excellent yields and with high regioselectivity. This reaction proceeds smoothly in water at room temperature without the need for acid catalysis. (c) 2007 Elsevier Ltd. All rights reserved.