Journal
ADVANCED MATERIALS
Volume 19, Issue 23, Pages 4238-+Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.200700941
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A novel gene delivery vector based on the ability of a synthetic amphiphilic block copolymer to mimic biological phospholipids by forming membrane-enclosed structures, specifically nanometer-sized vesicles, is presented. A pH-sensitive diblock copolymer forms vesicles (polymersomes) at neutral pH, and dissolves completely as unimers at endocytic pH (see figure). GFP-encoding plasmid DNA are successfully encapsulated inside the polymer vesicles, and delivered intracellularly.
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