Journal
ANALYTICA CHIMICA ACTA
Volume 604, Issue 2, Pages 165-169Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.aca.2007.10.016
Keywords
telomere DNA; gold nanoparticles; plasmon resonance light scattering; potassium ion; single point energy calculation
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It has been reported that adsorption of uncoiled DNA (u-DNA) on the surface of gold nanoparticles (Au-NPs) can prevent the nanoparticle suspensions from aggregation even if in salt medium. Herein we report that quadruplex DNA (q-DNA), which is formed from uncoiled telomere DNA, via intramolecular hydrogen bonds in the presence of potassium ion, cannot keep Au-NPs stable, and the q-DNA/Au-NPs coexisting suspensions display aggregation tendency giving plasmon resonance light scattering (PRLS) signals of Au-NPs. Mechanism investigations through a single point energy calculation on u- and q-structures of telomere DNA showed that q-DNA, compared with u-DNA, has a much higher surface negative charge density, symmetrical charge distribution and well self-structural stabilization, could not be adsorbed on the surface of Au-NPs. (c) 2007 Elsevier B.V. All rights reserved.
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