Journal
VACCINE
Volume 25, Issue 50, Pages 8480-8485Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2007.08.061
Keywords
yellow fever; yellow fever vaccine-associated viscerotropic disease; yellow fever vaccination
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Yellow fever vaccine-associated viscerotropic disease (YEL-AVD) is a rare complication of yellow fever (YF) vaccination. A previously healthy 22-year-old female died following YF vaccination despite aggressive measures. Serial viral load titers, cytokine levels and host genetic factors were evaluated in an attempt to understand this unusual and lethal outcome. The patient's high-titer vaccine viremia and possibly related minor genetic anomalies provide clues to exploring the etiology of YEL-AVD. (c) 2007 Elsevier Ltd. All rights reserved.
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