Journal
NEURON
Volume 56, Issue 5, Pages 771-783Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2007.11.008
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Funding
- NIMH NIH HHS [R01 MH054671, R01 MH054671-09] Funding Source: Medline
- NINDS NIH HHS [R01 NS034994, R01 NS034994-11] Funding Source: Medline
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The major part of the brain's energy budget (similar to 60%-80%) is devoted to its communication activities. While inhibition is critical to brain function, relatively little attention has been paid to its metabolic costs. Understanding how inhibitory interneurons contribute to brain energy consumption (brain work) is not only of interest in understanding a fundamental aspect of brain function but also in understanding functional brain imaging techniques which rely on measurements related to blood flow and metabolism. Herein we examine issues relevant to an assessment of the work performed by inhibitory interneurons in the service of brain function.
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