Journal
PHYSICS IN MEDICINE AND BIOLOGY
Volume 52, Issue 23, Pages N531-N537Publisher
IOP PUBLISHING LTD
DOI: 10.1088/0031-9155/52/23/N01
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Optical micro- angiography ( OMAG) is a recently developed method of imaging localized blood perfusion at capillary level resolution within microcirculatory beds. This paper reports that the OMAG is capable of directional blood perfusion mapping in vivo. This is achieved simply by translating the mirror located in the reference arm back and forth while 3D imaging is performed. The mirror which moves toward the incident beam gives the blood perfusion that flows away from the beam direction and vice versa. The approach is experimentally demonstrated by imaging of a flow phantom and then cerebrovascular perfusion of a live mouse with cranium intact.
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