4.7 Article

Encapsulation of moxifloxacin within poly(butyl cyanoacrylate) nanoparticles enhances efficacy against intracellular Mycobacterium tuberculosis

Journal

INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 345, Issue 1-2, Pages 154-162

Publisher

ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2007.05.062

Keywords

macrophage; moxifloxacin; M. Tuberculosis; nanoparticles; poly(butyl cyanoacrylate)

Funding

  1. NIAID NIH HHS [R21 AI 055284-A] Funding Source: Medline

Ask authors/readers for more resources

Macrophages in the lungs are the most important cell type supporting replication of Mycobacterium tuberculosis in humans. The objective of this study was to investigate whether the effect of moxifloxacin against M. tuberculosis residing in macrophages could be improved by encapsulation of the drug in the biodegradable nanoparticles, which are known to accumulate in macrophages upon intravenous administration. To accomplish this, moxifloxacin was encapsulated in poly(butyl cyanoacrylate) (PBCA) nanoparticles. Encapsulated moxifloxacin accumulated in macrophages approximately three-fold times more efficiently than the free drug, and was detected in the cells for at least six times longer than free moxifloxacin at the same extracellular concentration. Inhibition of intracellular M. tuberculosis growth with encapsulated moxifloxacin was achieved at the concentration of 0.1 mu g/ml, whereas the same effect with free MX required a concentration of 1 mu g/ml. Nanoparticles observed within the macrophage cytoplasm were distributed throughout the cytoplasm, sometimes in the vicinity of intracellular bacteria. (c) 2007 Elsevier B.V. All rights reserved.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available