Journal
OPTICS EXPRESS
Volume 15, Issue 25, Pages 17433-17442Publisher
OPTICAL SOC AMER
DOI: 10.1364/OE.15.017433
Keywords
-
Categories
Funding
- NIBIB NIH HHS [K25 EB006011-02, K25 EB006011] Funding Source: Medline
Ask authors/readers for more resources
The development of surface enhanced Raman scattering (SERS) detection has made Raman spectroscopy relevant for highly sensitive lab-on-a-chip bio/chemical sensors. Despite the tremendous benefit in specificity that a Raman-based sensor can deliver, development of a lab-on-a-chip SERS tool has been limited thus far. In this work, we utilize an optofluidic ring resonator (OFRR) platform to develop a SERS-based detection tool with integrated microfluidics. The liquid core optical ring resonator (LCORR) serves both as the microfluidic sample delivery mechanism and as a ring resonator, exciting the metal nanoclusters and target analytes as they pass through the channel. Using this OFRR approach and R6G as the analyte, we have achieved a measured detection limit of 400 pM. The measured Raman signal in this case is likely generated by only a few hundred R6G molecules, which foreshadows the development of a SERS-based lab-on-a-chip bio/chemical sensor capable of detecting a low number of target analyte molecules. (c) 2007 Optical Society of America.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available