Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 104, Issue 50, Pages 20137-20141Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0707383104
Keywords
repetitive transcranial magnetic stimulation; semantic cognition; temporal pole
Categories
Funding
- Medical Research Council [G0501632] Funding Source: researchfish
- MRC [G0501632] Funding Source: UKRI
- Wellcome Trust [078734/Z/05/Z] Funding Source: Wellcome Trust
- Medical Research Council [G0501632] Funding Source: Medline
- Wellcome Trust [078734/Z/05/Z] Funding Source: Medline
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Studies of semantic dementia and PET neurolimaging investigations suggest that the anterior temporal lobes (ATL) are a critical substrate for semantic representation. In stark contrast, classical neurological models of comprehension do not include ATL, and likewise functional MRI studies often fail to show activations in the ATL, reinforcing the classical view. Using a novel application of low-frequency, repetitive transcranial magnetic stimulation [rTMS) over the ATL, we demonstrate that the behavioral pattern of semantic dementia can be mirrored in neurologically intact participants: Specifically, we show that temporary disruption to neural processing in the ATL produces a selective semantic impairment leading to significant slowing in both picture naming and word comprehension but not to other equally demanding, nonsemantic cognitive tasks.
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