Journal
FEBS LETTERS
Volume 581, Issue 29, Pages 5573-5578Publisher
WILEY
DOI: 10.1016/j.febslet.2007.10.063
Keywords
CarO; Carbapenem resistance; L-ornithine uptake; basic amino acids uptake; outer membrane channel; Acinetobacter baumannii
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We previously associated the emergence of carbapenem resistance in Acinetobacter baumannii with the loss of an outer membrane (OM) protein designated CarO. CarO was found essential for L-ornithine uptake: CarO-deficient strains were specifically impaired to grow only on L-ornithine, and failed to incorporate L-[C-14] ornithine from the medium. L-arginine, and histidine and lysine to a lower extent, could effectively compete for L-[C-14] ornithine uptake. L-ornithine also reduced A. baumannii sensitivity to imipenem, suggesting that both compounds compete for uptake. The overall results indicate that CarO participates in the selective uptake of L-ornithine, carbapenems, and other basic amino acids in A. baumannii. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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