Journal
JOURNAL OF NEUROSCIENCE
Volume 27, Issue 50, Pages 13667-13679Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.2888-07.2007
Keywords
thalamocortical; axon guidance; cell adhesion molecule; semaphorin; neuropilin; somatosensory
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Funding
- NIMH NIH HHS [MH064056] Funding Source: Medline
- NINDS NIH HHS [NS049109, P30NS0445892] Funding Source: Medline
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We report a cooperation between the neural adhesion molecule close homolog of L1 (CHL1) and the semaphorin 3A (Sema3A) receptor, neuropilin 1 (Npn1), important for establishment of area-specific thalamocortical projections. CHL1 deletion in mice selectively disrupted the projection of somatosensory thalamic axons from the ventrobasal (VB) nuclei, causing them to shift caudally and target the visual cortex. At the ventral telencephalon, an intermediate target with graded Sema3A expression, VB axons were caudally shifted in CHL1(-) embryos and in Npn1Sema(-/-) mutants, in which axons are nonresponsive to Sema3A. CHL1 colocalized with Npn1 on thalamic axons, and associated with Npn1 through a sequence in the CHL1 Ig1 domain that was required for Sema3A- induced growth cone collapse. These results identify a novel function for CHL1 in thalamic axon responsiveness to ventral telencephalic cues, and demonstrate a role for CHL1 and Npn1 in establishment of proper targeting of specific thalamocortical projections.
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