4.8 Article

Polymer-caged lipsomes: A pH-Responsive delivery system with high stability

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 129, Issue 49, Pages 15096-+

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ja070748i

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Funding

  1. NCI NIH HHS [P30CA060553, U54CA119341] Funding Source: Medline

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Polymer-incorporated liposomes were prepared from preformed liposomes and a cholesterol-functionalized poly(acrylic acid) additive via a simple drop-in procedure. These modified liposomes possess surface-active carboxylate groups that can be cross-linked with telechelic 2,2'-(ethylenedioxy)bis(ethylamine) linkers, resulting in polymer-caged liposomes (PCLs) that are highly stable and have tunable pH-sensitive responses.

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