Journal
DEVELOPMENTAL BIOLOGY
Volume 312, Issue 2, Pages 533-544Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ydbio.2007.09.056
Keywords
neural crest; cadherin; EMT; delamination; cell adhesion; (E)migration; chick embryo
Categories
Funding
- NICHD NIH HHS [K99 HD055034-01, K99-HD055034, K99 HD055034] Funding Source: Medline
- NINDS NIH HHS [R01 NS036585, R37 NS036585, R01 NS036585-04, NS36585] Funding Source: Medline
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Neural crest cells originate in the dorsal neural tube but subsequently undergo an epithelial-to-mesenchymal transition (EMT), delaminate, and migrate to diverse locations in the embryo where they contribute to a variety of derivatives. Cadherins are a family of cell-cell adhesion molecules expressed in a broad range of embryonic tissues, including the neural tube. In particular, cadherin6B (Cad6B) is expressed in the dorsal neural tube prior to neural crest emigration but is then repressed by the transcription factor Snail2, expressed by premigratory and early migrating cranial neural crest cells. To examine the role of Cad6B during neural crest EMT, we have perturbed Cad6B protein levels in the cranial neural crest-forming region and have examined subsequent effects on emigration and migration. The results show that knock-down of Cad6B leads to premature neural crest cell emigration, whereas Cad6B overexpression disrupts migration. Our data reveal a novel role for Cad6B in controlling the proper timing of neural crest emigration and delamination from the neural tube of the avian embryo. (c) 2007 Elsevier Inc. All rights reserved.
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