Journal
TALANTA
Volume 74, Issue 3, Pages 308-317Publisher
ELSEVIER
DOI: 10.1016/j.talanta.2007.10.014
Keywords
nanomaterials; nanoparticles; immunosensors; immunoassays; carbon nanotubes; biomarkers
Categories
Funding
- NIEHS NIH HHS [U54 ES016015-020003, U54 ES016015, U54 ES016015-010003, U54 ES16015] Funding Source: Medline
- NINDS NIH HHS [U01 NS058161-01, U01 NS058161-03, U01 NS058161-02, U01 NS058161] Funding Source: Medline
- NIOSH CDC HHS [R01 OH008173, R01 OH008173-01] Funding Source: Medline
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This article reviews recent advances in nanomaterial labels in electrochemical immunosensors and immunoassays. Various nanomaterial labels are discussed, including colloidal gold/silver, semiconductor nanoparticles, and markers loaded nanocarriers (carbon nanotubes, apoferritin, silica nanoparticles, and liposome beads). The enormous signal enhancement associated with the use of nanomaterial labels and with the formation of nanomaterial-antibody-antigen assemblies provides the basis for ultrasensitive electrochemical detection of disease-related protein biomarkers, biothreat agents, or infectious agents. In general, all endeavors cited here are geared to achieve one or more of the following goals: signal amplification by several orders of magnitude, lower detection limits, and detecting multiple targets. (c) 2007 Elsevier B.V. All rights reserved.
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