4.5 Article

Syntheses of novel myxopyronin B analogs as potential inhibitors of bacterial RNA polymerase

Journal

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 17, Issue 24, Pages 6797-6800

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2007.10.017

Keywords

myxopyronin B; antibiotics; antibacterial; curtius rearrangement; ortholithiation

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Based upon observations from our initial findings, additional myxopyronin B analogs have been prepared and tested for in vitro inhibitory activity against DNA-dependent RNA polymerase and antibacterial activity against Escherichia coli and Staphylococcus aureus. (c) 2007 Elsevier Ltd. All rights reserved.

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