Journal
PSYCHIATRY RESEARCH-NEUROIMAGING
Volume 156, Issue 3, Pages 257-261Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.pscychresns.2007.05.001
Keywords
MRI; HPA axis; childhood trauma
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This study used magnetic resonance imaging to examine pituitary gland volume (PGV) in teenage patients with a first presentation of borderline personality disorder (BPD). No difference in PGV was observed between healthy controls (n=20) and the total BPD cohort (n=20). However, within the BPD cohort, those exposed to childhood trauma (n=9) tended to have smaller pituitaries (- 18%) than those with no history of childhood trauma (n = 10). These preliminary findings suggest that exposure to childhood trauma, rather than BPD, per se, might be associated with reduced PGV, possibly reflecting hypothalamic-pituitary-adrenal axis dysfunction. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
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