Journal
JOURNAL OF CELLULAR BIOCHEMISTRY
Volume 102, Issue 6, Pages 1400-1404Publisher
WILEY-LISS
DOI: 10.1002/jcb.21609
Keywords
tumor suppressor genes; Rb family; pRb2/p130; E2F; cell cycle; gene expression
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Tumor suppressor pRb/p105, pRb/p107, and pRb2/p130 genes belong to the retinoblastoma (Rb) gene family. The members of the Rb gene family and the transcription factor E2F play an essential role in regulating cell cycle and, consequently, cell proliferation. This mini-review describes the mechanisms by which Rb family members and E2F regulate cell cycle progression. J. Cell. Biochem. 102: 1400-1404, 2007. (c) 2007 Wiley-Liss, Inc.
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