Journal
CHEMPHYSCHEM
Volume 8, Issue 18, Pages 2595-2602Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cphc.200700434
Keywords
density functional calculations; nitrogen oxides; nitrotyrosine; reaction mechanisms; tyrosyl radical
Ask authors/readers for more resources
The present study employs a complete theoretical investigation, at the B3LYP/cc-pVTZ level of theory, of the interactions between the tyrosyl radical and nitric oxide, exploring in detail the nitrotyrosine formation radical mechanism. Tyrosyl radicals play an essential role in catalytic reactions of numerous enzymes and biological systems have regulated appropriate mechanisms for their formation. Nitric oxide reacts with the tyrosyl radical and affords a weak intermediate complex which, through a sequence of non-ionic water catalyzed and biologically feasible intermediate reactions, yields the iminoxyl radical. The iminoxyl radical further combines with hydroxyl radical, a species present in pathophysiological conditions, to yield nitrotyrosine.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available