Journal
ORGANIC LETTERS
Volume 9, Issue 26, Pages 5521-5524Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol7024718
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- NIGMS NIH HHS [GM58160] Funding Source: Medline
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A modular and practical synthesis of highly substituted oxazoles has been developed. The transformation consists of a sequential copper-catalyzed amidation of vinyl halides followed by cyclization promoted by iodine. A wide variety of functionalized oxazoles and polyazoles can be obtained in a selective manner from simple and easily accessible precursors.
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