4.8 Article

Biaryl synthesis via palladium-catalyzed aryne multicomponent coupling

Journal

ORGANIC LETTERS
Volume 9, Issue 26, Pages 5589-5592

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol702584t

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Aryl iodides have been introduced as electrophiles in the three-component Heck coupling of arynes. Following optimization studies to favor three- versus two-component coupling, the reaction proceeds in good yield to afford a variety of functionalized biaryls.

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