4.8 Article

Simple palladium(II) precatalyst for Suzuki-Miyaura couplings: Efficient reactions of benzylic, aryl, heteroaryl, and vinyl coupling partners

Journal

ORGANIC LETTERS
Volume 9, Issue 26, Pages 5397-5400

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol702291r

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Funding

  1. Engineering and Physical Sciences Research Council [EP/D078776/1] Funding Source: researchfish
  2. EPSRC [EP/D078776/1] Funding Source: UKRI

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trans-PdBr(N-Succ)(PPh3)(2) (1) is a universally effective precatalyst for Suzuki-Miyaura cross-couplings of benzylic halides with aryl- or heteroarylboronic acids. Substituted aryl halides and halogenated cyclic enones can be cross-coupled with aryl- or vinylboronic acids in excellent yields. Catalyst recycling is also demonstrated.

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