Journal
CHEMPHYSCHEM
Volume 8, Issue 18, Pages 2665-2670Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cphc.200700554
Keywords
colloids; drug analysis; lab-on-a-chip; microfluidics; Raman spectroscopy
Ask authors/readers for more resources
Herein, quantitative online monitoring of concentration fluctuations of different interesting drugs, namely, the phenothiazine promethazine as well as the anti-cancer agent mitoxantrone via surface enhanced Raman scattering assay based on a microfluidic device is demonstrated. With the applied liquid/liquid two-phase-segmented flow system we succeed in preventing the adhesion of nanoparticle aggregates to the channel walls which is necessary for a quantitative analysis. Even after repeated cycles no carry-over due to sedimentation of colloid particles is observed. To the best of our knowledge these are the first measurements applying a combination of a microfluidic device with SERS detection for quantitative online monitoring of fluctuations in drug concentrations over hours without use of aggressive chemicals for rinsing the chip, surfaces prior to each measurement.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available