Journal
ORGANIC LETTERS
Volume 9, Issue 26, Pages 5385-5388Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol702184n
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Funding
- NIGMS NIH HHS [P50 GM067082, P50-GM067082, GM-62924, R01 GM062924-05, R01 GM062924] Funding Source: Medline
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Oxidized amides, as represented by acyl aminals and acyl hemiaminals, are integral subunits of several natural products that exhibit useful biological activity. In this paper a multicomponent approach to these groups from acylimine intermediates is demonstrated. The acylimines; are accessed through a sequence of nitrile hydrozirconation and acylation, making this highly versatile amide synthesis useful for a range of applications in target- and diversity-oriented synthesis.
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