Journal
FEBS LETTERS
Volume 581, Issue 30, Pages 5911-5916Publisher
WILEY
DOI: 10.1016/j.febslet.2007.11.073
Keywords
thyroid hormone; mitochondria; uncoupling; 3,5-diiodothyronine
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We investigated the mechanism by which 3,5-diiodo-L- thyronine (T2) affects skeletal muscle mitochondrial bioenergetic parameters following its acute administration to hypothyroid rats. One hour after injection, T2 increased both coupled and uncoupled respiration rates by +27% and +42%, respectively. Top-down elasticity analysis revealed that these effects were the result of increases in the substrate oxidation and mitochondrial uncoupling. Discriminating between proton-leak and redox-slip processes, we identified an increased mitochondrial proton conductance as the pathway'' underlying the effect of T2 on mitochondrial uncoupling. As a whole, these results may provide a mechanism by which T2 rapidly affects energy metabolism in hypothyroid rats. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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