Journal
FEBS LETTERS
Volume 581, Issue 30, Pages 5759-5764Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2007.11.043
Keywords
circadian clock; control of period length; Neurospora
Funding
- NIGMS NIH HHS [P01 GM068087, GM68087, R01 GM034985-23, R37 GM034985, R01 GM083336, P01 GM068087-05, GM34985, R01 GM034985, R01 GM083336-20, GM83336] Funding Source: Medline
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The large (1) and small (s) isoforms of FREQUENCY (FRQ) are elements of interconnected feedback loops of the Neurospora circadian clock. The expression ratio of 1-FRQ vs. s-FRQ is regulated by thermosensitive splicing of an intron containing the initiation codon for 1-FRQ. We show that this splicing is dependent on light and temperature and displays a circadian rhythm. Strains expressing only 1-FRQ or s-FRQ support short and long temperature-compensated circadian rhythms, respectively. The thermosensitive expression ratio of FRQ isoforms influences period length in wt. Our data indicate that differential expression of FRQ isoforms is not required for temperature compensation but rather provides a means to. ne-tune period length in response to ambient temperature. (C) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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