Journal
TETRAHEDRON
Volume 63, Issue 52, Pages 12968-12974Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2007.10.032
Keywords
-
Categories
Ask authors/readers for more resources
A series of 7-amino- and polyaminosterol analogues of squalamine and trodusquemine were synthesized involving a new stereo-selective titanium reductive amination reaction in high chemical yields of up to 95% in numerous cases. These derivatives were evaluated for their in vitro antimicrobial properties against human pathogens. All the compounds present excellent activities against Gram-positive bacteria exhibiting similar results against Staphylococcus aureus and Streptococcus faecalis with minimum inhibitory concentrations (MICs) varying from 2.5 to 10 mu g/mL. Numerous derivatives possess also MICs against Gram-negative Escherichia coli bacteria (MICs varying from 2.5 to 10 mu g/mL) suggesting that nature of the amino group attached to the sterol moiety plays an important role on the activities of such products. (c) 2007 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available